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On the definition of a criterion of immunogenicity

Pradeu, Thomas and Carosella, Edgardo D. (2006) On the definition of a criterion of immunogenicity. [Preprint]

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    Abstract

    The main objective of immunology is to establish why and when an immune response occurs, that is, to determine a criterion of immunogenicity. According to the consensus view, the proper criterion of immunogenicity lies in the discrimination between self and nonself. Here we challenge this consensus by suggesting a simpler and more comprehensive criterion, the criterion of continuity (CC). Moreover, we show that this criterion may be considered as an interpretation of the immune 'self'. We conclude that immunologists can continue to speak of the self, provided that they admit that the self/nonself discrimination is not an adequate criterion of immunogenicity.


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    Item Type: Preprint
    Keywords: Self, Nonself, Continuity, Tolerance, Immunogenicity
    Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
    Depositing User: Thomas Pradeu
    Date Deposited: 22 Nov 2006
    Last Modified: 07 Oct 2010 11:14
    Item ID: 3062
    URI: http://philsci-archive.pitt.edu/id/eprint/3062

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