PhilSci Archive

Biometric and Developmental Gene-Environment Interaction: Looking Back, Moving Forward

Tabery, James (2007) Biometric and Developmental Gene-Environment Interaction: Looking Back, Moving Forward. [Preprint]

[img] Microsoft Word (.doc)
Download (6Mb)

    Abstract

    I provide a history of research on G×E in this article, showing that there have actually been two distinct concepts of G×E since the very origins of this research. R. A. Fisher introduced what I call the biometric concept of G×E, or G×EB, while Lancelot Hogben introduced what I call the developmental concept of G×E, or G×ED. Much of the subsequent history of research on G×E has largely consisted in the separate legacies of these separate concepts, along with the (sometimes acrimonious) disputes that have arisen time and again when employers of each have argued over the appropriate way to conceptualize the phenomenon. With this history in place, I then consider more recent attempts to distinguish between different concepts of G×E, paying particular attention to the commonly made distinction between “statistical interaction” and “interactionism,” and also Michael Rutter’s distinction between “statistical interaction” and “the biological concept of interaction.” I argue that the history of the separate legacies of G×EB and G×ED better supports Rutter’s analysis of the situation, and that this analysis best paves the way for an integrative relationship between the various scientists investigating the place of G×E in the etiology of complex traits.


    Export/Citation:EndNote | BibTeX | Dublin Core | ASCII/Text Citation (Chicago) | HTML Citation | OpenURL
    Social Networking:

    Item Type: Preprint
    Keywords: Causation, Genetics, Gene-Environment Interaction, Nature-Nurture Debate, Analysis of Variance, Biometry, Developmental Biology, Integration, Pluralism
    Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
    Specific Sciences > Biology
    General Issues > Causation
    Specific Sciences > Biology > Developmental Biology
    Depositing User: James Tabery
    Date Deposited: 27 Sep 2008
    Last Modified: 07 Oct 2010 11:17
    Item ID: 4207
    URI: http://philsci-archive.pitt.edu/id/eprint/4207

    Actions (login required)

    View Item

    Document Downloads