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From molecules to behavior and the clinic: Integration in Chronobiology

Bechtel, William (2012) From molecules to behavior and the clinic: Integration in Chronobiology. [Preprint]

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    Abstract

    Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system.


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    Item Type: Preprint
    Keywords: mechanistic explanation, dynamic mechanistic explanation, circadian rhythms, integration in science
    Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
    General Issues > Explanation
    Specific Sciences > Biology > Neuroscience
    General Issues > Reductionism/Holism
    Depositing User: Professor William Bechtel
    Date Deposited: 25 Jul 2012 11:35
    Last Modified: 25 Jul 2012 11:35
    Item ID: 9253
    URI: http://philsci-archive.pitt.edu/id/eprint/9253

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