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Making Sense of Downward Causation in Manipulationism. With Illustrations from Cancer Research

Malaterre, Christophe (2011) Making Sense of Downward Causation in Manipulationism. With Illustrations from Cancer Research. History and Philosophy of the Life Sciences, 33 (4). pp. 537-562.

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Abstract

Many researchers consider cancer to have molecular causes, namely mutated genes that result in abnormal cell proliferation (e.g. Weinberg 1998); yet for others, the causes of cancer are to be found not at the molecular level but at the tissue level and carcinogenesis would consist in a disrupted tissue organization with downward causation effects on cells and cellular components (e.g. Sonnenschein & Soto 2008). In this contribution, I ponder how to make sense of such downward causation claims. Adopting a manipulationist account of causation (Woodward 2003), I propose a formal definition of downward causation, and discuss further requirements (in light of Baumgartner 2009). I then show that such an account cannot be mobilized in support of non-reductive physicalism (contrary to Raatikainen 2010). However, I also argue that such downward causation claims might point at particularly interesting dynamic properties of causal relationships that might prove salient in characterizing causal relationships (following Woodward 2010).


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Malaterre, Christophemalaterre.christophe@uqam.ca
Keywords: Downward causation, manipulationism, levels of causation, causal granularity, cancer research
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Causation
Depositing User: Christophe Malaterre
Date Deposited: 11 Apr 2013 11:56
Last Modified: 11 Apr 2013 11:56
Item ID: 9667
Journal or Publication Title: History and Philosophy of the Life Sciences
Official URL: http://www.hpls-szn.com/articles.asp?id=145&book=3...
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
General Issues > Causation
Date: 2011
Page Range: pp. 537-562
Volume: 33
Number: 4
URI: http://philsci-archive.pitt.edu/id/eprint/9667

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