Animal Models of Depression in Neuropsychopharmacology qua Feyerabendian Philosophy of Science

Wright, Cory (2002) Animal Models of Depression in Neuropsychopharmacology qua Feyerabendian Philosophy of Science.

Abstract

The neuropsychopharmacological methods and theories used to investigate the nature of depression have been viewed as suspect for a variety of philosophical and scientific reasons. Much of this criticism aims to demonstrate that biochemical- and neurological-based theories of this mental illness are defective, due in part because the methods used in their service are consistently invalidated, failing to induce depression in pre-clinical animal models. Neuropsychopharmacologists have been able to stave off such criticism by showing that their methods are context and domain-sensitive, and that the worth of an animal model is relative to its purpose – thereby creating logical space for the question of whether there could ever be a “good” animal model of depression. I contend that this sort of response implicitly leans on Feyerabendian principles in the philosophy of science, and exemplify this connection using a standard taxonomy of behavioral models of depression. I then take one central Feyerabendian principle – methodological and theoretical pluralism – and show how it maps onto the neuropsychopharmacological research tradition as it is currently practiced.