Laurent, Paôline and Jolivel, Valérie and Manicki, Pauline and Chiu, Lynn and Contin-Bordes, Cécile and Truchetet, Marie-Elise and Pradeu, Thomas
(2017)
Immune-Mediated Repair: A Matter of Plasticity.
Frontiers in Immunology, 8.
ISSN 1664-3224
Abstract
Though the immune system is generally defined as a system of defense, it is increasingly
recognized that the immune system also plays a crucial role in tissue repair and its potential dysregulations. In this review, we explore how distinct immune cell types are involved
in tissue repair and how they interact in a process that is tightly regulated both spatially
and temporally. We insist on the concept of immune cell plasticity which, in recent years,
has proved fundamental for the success/understanding of the repair process. Overall,
the perspective presented here suggests that the immune system plays a central role in
the physiological robustness of the organism, and that cell plasticity contributes to the
realization of this robustness.
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