Fagan, Melinda B. (2015) Crucial Stem Cell Experiments? Stem Cells, Uncertainty, and Single-Cell Experiments. THEORIA. An International Journal for Theory, History and Foundations of Science, 30 (2). pp. 183-205. ISSN 2171-679X
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Abstract
I have previously argued that stem cell experiments cannot demonstrate that a single cell is a stem cell (Fagan 2013a, b). Laplane and others dispute this claim, citing experiments that identify stem cells at the single-cell level. This paper rebuts the counterexample, arguing that the alleged ‘crucial stem cell experiments’ do not measure self-renewal for a single cell, do not establish a single cell’s differentiation potential, and, if interpreted as providing results about single cells, fall into epistemic circularity. I then discuss the source of the dispute, locating it in differences between philosophical and experimental perspectives.
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| Item Type: | Published Article or Volume | ||||||
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| Additional Information: | ISSN: 0495-4548 (print) | ||||||
| Keywords: | experiment; stem cells; models; crucial experiments; in vivo/in vitro | ||||||
| Subjects: | Specific Sciences > Biology General Issues > Experimentation General Issues > History of Science Case Studies General Issues > Models and Idealization |
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| Depositing User: | Unnamed user with email theoria@ehu.es | ||||||
| Date Deposited: | 07 Jun 2016 13:09 | ||||||
| Last Modified: | 07 Jun 2016 13:09 | ||||||
| Item ID: | 12146 | ||||||
| Journal or Publication Title: | THEORIA. An International Journal for Theory, History and Foundations of Science | ||||||
| Publisher: | Euskal Herriko Unibertsitatea / Universidad del País Vasco | ||||||
| Official URL: | http://www.ehu.eus/ojs/index.php/THEORIA/article/v... | ||||||
| DOI or Unique Handle: | 10.1387/theoria.12707 | ||||||
| Subjects: | Specific Sciences > Biology General Issues > Experimentation General Issues > History of Science Case Studies General Issues > Models and Idealization |
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| Date: | May 2015 | ||||||
| Page Range: | pp. 183-205 | ||||||
| Volume: | 30 | ||||||
| Number: | 2 | ||||||
| ISSN: | 2171-679X | ||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/12146 |
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