Darden, Lindley and Pal, Lipika R. and Kundu, Kunal and Moult, John (2017) The Product Guides the Process: Discovering Disease Mechanisms. [Preprint]

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Abstract

The nature of the product to be discovered guides the reasoning to discover it. Biologists and medical researchers often search for mechanisms. The "new mechanistic philosophy of science" provides resources about the nature of biological mechanisms that aid the discovery of mechanisms. Here, we apply these resources to the discovery of mechanisms in medicine. A new diagrammatic representation of a disease mechanism chain indicates both what is known and, most significantly, what is not known at a given time, thereby guiding the researcher and collaborators in discovery. Mechanisms of genetic diseases provide the examples.

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Item Type:	Preprint
Creators:	Creators Email ORCID Darden, Lindley darden@umd.edu 0000-0002-5087-7850 Pal, Lipika R. lray1@umd.edu 0000-0002-3390-110X Kundu, Kunal kkundu@umd.edu 0000-0002-4452-4290 Moult, John jmoult@tunc.org 0000-0002-3012-2282
Keywords:	Discovery, Mechanism, Diagrams, Genetic Disease
Subjects:	Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Computation/Information Specific Sciences > Medicine
Depositing User:	Ms. Lindley Darden
Date Deposited:	01 Jul 2017 20:55
Last Modified:	13 Aug 2017 16:13
Item ID:	13176
Subjects:	Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Computation/Information Specific Sciences > Medicine
Date:	1 July 2017
URI:	https://philsci-archive.pitt.edu/id/eprint/13176

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