Tabery, James (2007) Biometric and Developmental Gene-Environment Interaction: Looking Back, Moving Forward. [Preprint]
Microsoft Word (.doc)
GxE-B_vs._GxE-D--Looking_Back,_Moving_Forward_(Tabery).doc Download (6MB) |
Abstract
I provide a history of research on G×E in this article, showing that there have actually been two distinct concepts of G×E since the very origins of this research. R. A. Fisher introduced what I call the biometric concept of G×E, or G×EB, while Lancelot Hogben introduced what I call the developmental concept of G×E, or G×ED. Much of the subsequent history of research on G×E has largely consisted in the separate legacies of these separate concepts, along with the (sometimes acrimonious) disputes that have arisen time and again when employers of each have argued over the appropriate way to conceptualize the phenomenon. With this history in place, I then consider more recent attempts to distinguish between different concepts of G×E, paying particular attention to the commonly made distinction between “statistical interaction” and “interactionism,” and also Michael Rutter’s distinction between “statistical interaction” and “the biological concept of interaction.” I argue that the history of the separate legacies of G×EB and G×ED better supports Rutter’s analysis of the situation, and that this analysis best paves the way for an integrative relationship between the various scientists investigating the place of G×E in the etiology of complex traits.
Export/Citation: | EndNote | BibTeX | Dublin Core | ASCII/Text Citation (Chicago) | HTML Citation | OpenURL |
Social Networking: |
Item Type: | Preprint | ||||||
---|---|---|---|---|---|---|---|
Creators: |
|
||||||
Keywords: | Causation, Genetics, Gene-Environment Interaction, Nature-Nurture Debate, Analysis of Variance, Biometry, Developmental Biology, Integration, Pluralism | ||||||
Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Biology General Issues > Causation Specific Sciences > Biology > Developmental Biology |
||||||
Depositing User: | James Tabery | ||||||
Date Deposited: | 27 Sep 2008 | ||||||
Last Modified: | 07 Oct 2010 15:17 | ||||||
Item ID: | 4207 | ||||||
Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Biology General Issues > Causation Specific Sciences > Biology > Developmental Biology |
||||||
Date: | January 2007 | ||||||
URI: | https://philsci-archive.pitt.edu/id/eprint/4207 |
Monthly Views for the past 3 years
Monthly Downloads for the past 3 years
Plum Analytics
Actions (login required)
View Item |