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Varieties of Living Things: Life at the Intersection of Lineage and Metabolism

Dupré, John and O'Malley, Maureen A (2009) Varieties of Living Things: Life at the Intersection of Lineage and Metabolism. Philosophy and Theory in Biology, 1 (201306). pp. 1-25. ISSN 1949-0739

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Abstract

We address three fundamental questions: What does it mean for an entity to be living? What is the role of inter-organismic collaboration in evolution? What is a biological individual? Our central argument is that life arises when lineage-forming entities collaborate in metabolism. By conceiving of metabolism as a collaborative process performed by functional wholes, which are associations of a variety of lineage-forming entities, we avoid the standard tension between reproduction and metabolism in discussions of life – a tension particularly evident in discussions of whether viruses are alive. Our perspective assumes no sharp distinction between life and non-life, and does not equate life exclusively with cellular or organismal status. We reach this conclusion through an analysis of the capabilities of a spectrum of biological entities, in which we include the pivotal case of viruses as well as prions, plasmids, organelles, intracellular and extracellular symbionts, unicellular and multicellular life-forms. The usual criterion for classifying many of the entities of our continuum as non-living is autonomy. This emphasis on autonomy is problematic, however, because even paradigmatic biological individuals, such as large animals, are dependent on symbiotic associations with many other organisms. These composite individuals constitute the metabolic wholes on which selection acts. Finally, our account treats cooperation and competition not as polar opposites but as points on a continuum of collaboration. We suggest that competitive relations are a transitional state, with multi-lineage metabolic wholes eventually outcompeting selfish competitors, and that this process sometimes leads to the emergence of new types or levels of wholes. Our view of life as a continuum of variably structured collaborative systems leaves open the possibility that a variety of forms of organized matter – from chemical systems to ecosystems – might be usefully understood as living entities.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Dupré, John
O'Malley, Maureen Am.a.o’malley@exeter.ac.uk
Keywords: Autonomy, collaboration, lineage formation, living, metabolic whole, non-living
Depositing User: Users 15304 not found.
Date Deposited: 12 Jun 2014 16:06
Last Modified: 12 Jun 2014 16:06
Item ID: 10737
Journal or Publication Title: Philosophy and Theory in Biology
Publisher: Michigan Publishing, University of Michigan Library
Official URL: http://dx.doi.org/10.3998/ptb.6959004.0001.003
DOI or Unique Handle: 10.3998/ptb.6959004.0001.003
Date: December 2009
Page Range: pp. 1-25
Volume: 1
Number: 201306
ISSN: 1949-0739
URI: http://philsci-archive.pitt.edu/id/eprint/10737

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