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Dissolving the missing heritability problem

Bourrat, Pierrick and Lu, Qiaoying (2016) Dissolving the missing heritability problem. In: UNSPECIFIED.

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Abstract

Heritability estimates obtained in genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This has been called the “missing heritability problem”. By analyzing and comparing these two kinds of methods, we first show that the estimates obtained by traditional methods involve some terms that GWAS do not. Second, the estimates obtained by GWAS do not take into account epigenetic factors transmitted across generations, whilst they are included in the estimates of traditional quantitative methods. Once these two factors are taken into account, we show that the missing heritability problem can be largely dissolved. Finally, we briefly contextualize our analysis within a current discussion on how non-additive factors relate to the heritability estimates in GWAS


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Item Type: Conference or Workshop Item (UNSPECIFIED)
Creators:
CreatorsEmailORCID
Bourrat, Pierrickp.bourrat@gmail.com
Lu, Qiaoyingqiaoy.lu@gmail.com
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
Depositing User: Ms. Qiaoying Lu
Date Deposited: 24 Oct 2016 13:27
Last Modified: 24 Oct 2016 13:27
Item ID: 12501
Subjects: Specific Sciences > Biology > Molecular Biology/Genetics
Date: 3 November 2016
URI: http://philsci-archive.pitt.edu/id/eprint/12501

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