Pradeu, Thomas and Moreau, Jean-Francois (2019) CRISPR-Cas immunity: beyond nonself and defence. Biology & Philosophy, 34 (1). ISSN 0169-3867
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Official URL: http://doi.org/10.1007/s10539-018-9666-7
Abstract
In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements (for example in DNA repair) and tolerate exogenous elements (for example some phages). We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.
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| Item Type: | Published Article or Volume | |||||||||
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| Depositing User: | Thomas Pradeu | |||||||||
| Date Deposited: | 19 Oct 2020 02:48 | |||||||||
| Last Modified: | 19 Oct 2020 02:48 | |||||||||
| Item ID: | 18268 | |||||||||
| Journal or Publication Title: | Biology & Philosophy | |||||||||
| Official URL: | http://doi.org/10.1007/s10539-018-9666-7 | |||||||||
| DOI or Unique Handle: | 10.1007/s10539-018-9666-7 | |||||||||
| Date: | 2019 | |||||||||
| Volume: | 34 | |||||||||
| Number: | 1 | |||||||||
| ISSN: | 0169-3867 | |||||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/18268 |
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