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Beyond the dichotomy in vivo - in vitro: in silico

Garcia, Pio (2006) Beyond the dichotomy in vivo - in vitro: in silico. In: [2006] Models and Simulations (Paris, 2006). (Unpublished)

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    From the beginnings of the biochemistry as discipline, the dichotomy between in vivo- in vitro conditions has been in the center of their methodological discussions. With the growing influence of computer simulations - sometimes called "in silico" conditions-, a new methodological problem is added to biochemistry. However, "simulation" could be seen as a core concept that is in fact used in the in vivo - in vitro dichotomy. In this sense, in silico dimension could be considered as a natural extension of the classical dichotomy. From the way in which simulation is used on in vivo-in vitro dichotomy, we also suggest that the general idea of simulation proposed by Hartmann have to be redefined. The intuitive idea of simulation resting on “imitation” relationship, as a “process that imitates another process” (Hartmann 1996), has to be complemented by others methodological concepts like “isolation” or “disruption”.

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    Item Type: Conference or Workshop Item (UNSPECIFIED)
    Keywords: Simulation, Biochemistry
    Subjects: General Issues > Models and Idealization
    Conferences and Volumes: [2006] Models and Simulations (Paris, 2006)
    Depositing User: Pio Garcia
    Date Deposited: 08 Jun 2006
    Last Modified: 07 Oct 2010 11:14
    Item ID: 2777
    Public Domain: Yes

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