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Protective Microbiota: From Localized to Long-Reaching Co-Immunity

Chiu, Lynn and Bazin, Thomas and Truchetet, Marie-Elise and Schaeverbeke, Thierry and Delhaes, Laurence and Pradeu, Thomas (2017) Protective Microbiota: From Localized to Long-Reaching Co-Immunity. Frontiers in Immunology, 8. ISSN 1664-3224


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Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance localized within a microenvironment. This review shows that the protection against pathogens also involves the mitigation of pathogenic impact without eliminating the pathogens (i.e., “disease tolerance”) and the containment of microorganisms to prevent pathogenic spread. Protective microorganisms can have an impact beyond their niche, interfering with the entry, establishment, growth, and spread of pathogenic microorganisms. More fundamentally, we propose a series of conceptual clarifications in support of the idea of a “co-immunity,” where an organism is protected by both its own immune system and components of its microbiota.

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Item Type: Published Article or Volume
Chiu, Lynn
Bazin, Thomas
Truchetet, Marie-Elise
Schaeverbeke, Thierry
Delhaes, Laurence
Pradeu, Thomas
Depositing User: Thomas Pradeu
Date Deposited: 24 Oct 2020 19:47
Last Modified: 24 Oct 2020 19:47
Item ID: 18264
Journal or Publication Title: Frontiers in Immunology
Official URL:
DOI or Unique Handle: 10.3389/fimmu.2017.01678
Date: 2017
Volume: 8
ISSN: 1664-3224

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