Rondeau, Elena and Larmonier, Nicolas and Pradeu, Thomas and Bikfalvi, Andreas
(2019)
Characterizing causality in cancer.
eLife, 8.
ISSN 2050-084X
Abstract
Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.
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