Woodward, James and Kendler, Kenneth (2023) Polygene Risk Scores: A Philosophical Exploration. Philosophy of Medicine, 4 (1). pp. 1-21. ISSN 2692-3963
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Abstract
This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects. Although their purely predictive/correlational use is important, it is this tracking feature that contributes to their potential usefulness in other applications, such as genetic dissection, and their use as controls, which allow us, indirectly, to "see" more clearly the role of environmental variables.
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| Item Type: | Published Article or Volume | |||||||||
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| Keywords: | Polygene risk scores Genetic causation | |||||||||
| Subjects: | Specific Sciences > Medicine | |||||||||
| Depositing User: | Professor Alex Broadbent | |||||||||
| Date Deposited: | 07 Jul 2023 12:29 | |||||||||
| Last Modified: | 07 Jul 2023 12:29 | |||||||||
| Item ID: | 22289 | |||||||||
| Journal or Publication Title: | Philosophy of Medicine | |||||||||
| Publisher: | University Library System, University of Pittsburgh | |||||||||
| Official URL: | https://philmed.pitt.edu/philmed/article/view/156 | |||||||||
| DOI or Unique Handle: | 10.5195/pom.2023.156 | |||||||||
| Subjects: | Specific Sciences > Medicine | |||||||||
| Date: | 5 July 2023 | |||||||||
| Page Range: | pp. 1-21 | |||||||||
| Volume: | 4 | |||||||||
| Number: | 1 | |||||||||
| ISSN: | 2692-3963 | |||||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/22289 |
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