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Comparing the Strengths of Two Causes of an Effect − Zeroing-out, Adding-in, and the Need for Baselines

Maxwell, Matthew J. and Sober, Elliott (2025) Comparing the Strengths of Two Causes of an Effect − Zeroing-out, Adding-in, and the Need for Baselines. [Preprint]

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Abstract

Abstract: Suppose 50-year-old Sue now has lung cancer, due to the fact that C=c & A=g (meaning that Sue smoked c
cigarettes and inhaled g grams of asbestos over the previous 30 years), and that neither cause caused the other. Given this, a retrospective question arises – did one of those actual causes have a stronger influence than the other on her getting lung cancer? We propose a “zeroing-out” criterion for making sense of this question; it says that C=c was a stronger causal influence than A=g precisely when Pr(lung cancer | C=c & A=g) – Pr(lung cancer | C=0 & A=g) > Pr(lung cancer | C=c & A=g) – Pr(lung cancer | C=c & A=0). Zeroing-out uses Pr(lung cancer | C=c & A=g) as a baseline and relates that baseline to two counterfactual probabilities. We discuss how zeroing-out applies to three evolutionary examples − the influences of selection and drift on the fixation of an allele, the influences of group and individual selection on the evolution of altruism, and the influences of stabilizing selection and ancestral influence (aka “phylogenetic inertia”) on the evolution of tetrapody in land vertebrates. Zeroing-out differs from an “adding-in” criterion, which uses Sue’s probability of having lung cancer at age 50, given her actual state at age 20 (at which time she was cancer free and C=0 & A=0) as a baseline and asks whether her risk of having lung cancer at age 50 would be greater if C=c were true of the 30 years in between than it would be if A=g were true of those years. Zeroing-out and adding-in generate identical criteria for
comparing causal influences in this example because the probabilities are related “monotonically” (a concept we define). We then describe examples in which monotonicity fails and the two criteria differ. We prove theorems that describe when the two criteria disagree and when they do not. We then consider how zeroing-out and adding-in are related to six quantitative measures of causal strength that have been proposed. Inter alia, we discuss how our framework is related to interventionism.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Maxwell, Matthew J.mattjmaxwell42@gmail.com0000-0002-6835-3983
Sober, Elliottersober@wisc.edu
Keywords: causal baselines, comparing causal influences, drift and selection, evolution of altruism,interventionism, measures of causal influence, phylogenetic inertia, probabilistic causation, units of selection, zeroing-out
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Evolutionary Theory
General Issues > Causation
Depositing User: Matthew J. Maxwell
Date Deposited: 31 Dec 2025 12:44
Last Modified: 31 Dec 2025 12:44
Item ID: 27673
Subjects: Specific Sciences > Biology
Specific Sciences > Biology > Evolutionary Theory
General Issues > Causation
Date: January 2025
URI: https://philsci-archive.pitt.edu/id/eprint/27673

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