Bourrat, Pierrick and Lu, Qiaoying
(2016)
Dissolving the missing heritability problem.
In: UNSPECIFIED.
This is the latest version of this item.
Abstract
Heritability estimates obtained in genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This has been called the “missing heritability problem”. By analyzing and comparing these two kinds of methods, we first show that the estimates obtained by traditional methods involve some terms that GWAS do not. Second, the estimates obtained by GWAS do not take into account epigenetic factors transmitted across generations, whilst they are included in the estimates of traditional quantitative methods. Once these two factors are taken into account, we show that the missing heritability problem can be largely dissolved. Finally, we briefly contextualize our analysis within a current discussion on how non-additive factors relate to the heritability estimates in GWAS
Available Versions of this Item
Monthly Views for the past 3 years
Monthly Downloads for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[feed]](http://philsci-archive.pitt.edu/style/images/feed-icon-32x32.png){kind=icon}