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The discontinuity theory of immunity

Pradeu, Thomas and Vivier, Eric (2016) The discontinuity theory of immunity. Science Immunology, 1 (1). aag0479-aag0479. ISSN 2470-9468

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Abstract

Similar to many other biological systems, the immune system can be seen as a change-detection system. According to the discontinuity theory of immunity, the immune system responds to sudden changes in antigenic stimulation and is rendered tolerant by slow or continuous stimulation. This basic principle, which is supported by recent data on immune checkpoints in viral infections, cancers, and allergies, can be seen as a unifying framework for diverse immune responses.


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Pradeu, Thomas
Vivier, Eric
Depositing User: Thomas Pradeu
Date Deposited: 18 Oct 2020 02:37
Last Modified: 18 Oct 2020 02:37
Item ID: 18248
Journal or Publication Title: Science Immunology
Official URL: http://doi.org/10.1126/sciimmunol.aag0479
DOI or Unique Handle: 10.1126/sciimmunol.aag0479
Date: 2016
Page Range: aag0479-aag0479
Volume: 1
Number: 1
ISSN: 2470-9468
URI: http://philsci-archive.pitt.edu/id/eprint/18248

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