Bechtel, William (2012) From molecules to behavior and the clinic: Integration in Chronobiology. [Preprint]
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Abstract
Chronobiology, especially the study of circadian rhythms, provides a model scientific field in which philosophers can study how investigators from a variety of disciplines working at different levels of organization are each contributing to a multi-level account of the responsible mechanism. I focus on how the framework of mechanistic explanation integrates research designed to decompose the mechanism with efforts directed at recomposition that relies especially on computation models. I also examine how recently the integration has extended beyond basic research to the processes through which the disruption of circadian rhythms contributes to disease, including various forms of cancer. Understanding these linkages has been facilitated by discoveries about how circadian mechanisms interact with mechanisms involved in other physiological processes, including the cell cycle and the immune system.
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| Item Type: | Preprint | ||||||
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| Keywords: | mechanistic explanation, dynamic mechanistic explanation, circadian rhythms, integration in science | ||||||
| Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Explanation Specific Sciences > Neuroscience General Issues > Reductionism/Holism |
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| Depositing User: | Professor William Bechtel | ||||||
| Date Deposited: | 25 Jul 2012 15:35 | ||||||
| Last Modified: | 25 Jul 2012 15:35 | ||||||
| Item ID: | 9253 | ||||||
| Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Explanation Specific Sciences > Neuroscience General Issues > Reductionism/Holism |
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| Date: | 24 July 2012 | ||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/9253 |
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