Bourrat, Pierrick and Lu, Qiaoying (2017) Dissolving the Missing Heritability Problem. [Preprint]
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Abstract
Heritability estimates obtained from genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This phenomenon has been called the
“missing heritability problem.” By analyzing and comparing GWAS and traditional quantitative methods, we fi rst show that the estimates obtained from the latter involve some terms other than additive genetic variance, while the estimates from the former do not. Second, GWAS, when used to estimate heritability, do not take into account additive epigenetic factors transmitted across generations, while traditional quantitative methods do. Given these two points we show that the missing heritability problem can largely be dissolved.
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Item Type: | Preprint | |||||||||
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Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Biology > Molecular Biology/Genetics |
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Depositing User: | Mr Pierrick Bourrat | |||||||||
Date Deposited: | 17 Dec 2017 20:54 | |||||||||
Last Modified: | 17 Dec 2017 20:54 | |||||||||
Item ID: | 14215 | |||||||||
Journal or Publication Title: | Philosophy of Science | |||||||||
Official URL: | http://www.journals.uchicago.edu/doi/pdfplus/10.10... | |||||||||
Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Biology > Molecular Biology/Genetics |
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Date: | 5 December 2017 | |||||||||
URI: | https://philsci-archive.pitt.edu/id/eprint/14215 |
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