Baxter, Janella (2019) CRISPR-Cas Changing Biology? [Preprint]

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Abstract

Eugene V. Koonin argues that fundamental research of CRISPR-Cas mechanisms has (among other things) illuminated “fundamental principles of genome manipulation.” Koonin's discussion provides important philosophical insights for how we should understand the significance of CRISPR-Cas systems. Yet the analysis he provides is only part of a larger story. There is also a human element to the CRISPR-Cas story that concerns its development as a technology. Accounting for this part of CRISPR's history reveals that the story Koonin provides requires greater nuance. I'll show how CRISPR-Cas technologies are not “natural” genome editing systems, but (in part) artifacts of human ingenuity. Furthermore, I'll argue that the story of CRISPR-Cas is not “primarily about research into fundamental biological mechanisms”, but is instead about the intertwining of applied and fundamental research programs.

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Item Type:	Preprint
Creators:	Creators Email ORCID Baxter, Janella janella.baxter@gmail.com
Keywords:	CRISPR-Cas, genome engineering, basic and applied research
Subjects:	Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Experimentation General Issues > Technology
Depositing User:	Ms. Janella Baxter
Date Deposited:	12 May 2019 02:03
Last Modified:	12 May 2019 02:03
Item ID:	16004
DOI or Unique Handle:	https://doi.org/10.1007/s10539-018-9663-x
Subjects:	Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Experimentation General Issues > Technology
Date:	11 February 2019
URI:	https://philsci-archive.pitt.edu/id/eprint/16004

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