Ruiz-Narvaez, Edward A (2021) The emergent genome. [Preprint]

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Abstract

Current paradigm equates an organism’s genome with its complete DNA sequence. However, results from omics research show that the genome is more than the DNA sequence. For example, sequence alone does not determine multi-functionality of regulatory elements (e.g. enhancers, insulators). In addition, identity of genomic elements depends on cellular and temporal context. Based on these findings, the present work advances the hypothesis that the genome is an emergent entity resulting from epigenomics mechanisms. The genome can be understood as the mapping of identity-functions to elements along the DNA molecule. The mapping can vary across cellular types and developmental times. As consequence, the same organism can have multiple genomes regardless of the underlying DNA sequence. The proposed theory has major implications for the study of the hereditary basis of phenotypic traits, including diseases, and offers a new framework for future research.

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Item Type:	Preprint
Creators:	Creators Email ORCID Ruiz-Narvaez, Edward A eruiznar@umich.edu 0000-0002-0339-5824
Keywords:	genome, epigenome, emergence, philosophy of science
Subjects:	Specific Sciences > Biology > Function/Teleology Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease General Issues > Philosophers of Science
Depositing User:	Dr Edward Ruiz-Narvaez
Date Deposited:	28 May 2021 01:42
Last Modified:	28 May 2021 01:42
Item ID:	19089
Subjects:	Specific Sciences > Biology > Function/Teleology Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease General Issues > Philosophers of Science
Date:	21 May 2021
URI:	https://philsci-archive.pitt.edu/id/eprint/19089

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