Matthiessen, Dana (2017) Causal Concepts Guiding Model Specification in Systems Biology. [Preprint]
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Abstract
In this paper I analyze the process by which modelers in systems biology arrive at an adequate representation of the biological structures thought to underlie data gathered from high-throughput experiments. Contrary to claims that causal claims and explanations are rare in systems biology, I argue that in many studies of gene regulatory networks modelers aim at a representation of causal structure. In addressing modeling challenges, they draw on assumptions informed by theory and pragmatic considerations in a manner that is guided by an interventionist conception of causal structure. While doubts have been raised about the applicability of this notion of causality to complex biological systems, it is here seen to be an adequate guide to inquiry.
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Item Type: | Preprint | ||||||
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Keywords: | Models; Causation; Systems Biology; Cellular Networks; Causal Graphs | ||||||
Subjects: | Specific Sciences > Biology General Issues > Causation Specific Sciences > Complex Systems General Issues > Models and Idealization |
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Depositing User: | Dana Matthiessen | ||||||
Date Deposited: | 25 Aug 2023 13:58 | ||||||
Last Modified: | 25 Aug 2023 13:58 | ||||||
Item ID: | 22449 | ||||||
Subjects: | Specific Sciences > Biology General Issues > Causation Specific Sciences > Complex Systems General Issues > Models and Idealization |
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Date: | 2017 | ||||||
URI: | https://philsci-archive.pitt.edu/id/eprint/22449 |
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