Hey, Spencer Phillips (2015) Judging Quality and Coordination in Biomarker Diagnostic Development. THEORIA. An International Journal for Theory, History and Foundations of Science, 30 (2). pp. 207-227. ISSN 2171-679X
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Abstract
What makes a high-quality biomarker experiment The success of personalised medicine hinges on the answer to this question. In this paper, I argue that judgment about the quality of biomarker experiments is mediated by the problem of theoretical underdetermination. That is, the network of biological and pathophysiological theories motivating a biomarker experiment is sufficiently complicated that it often frustrates valid interpretation of the experimental results. Drawing on a case-study in biomarker diagnostic development from neurooncology, I argue that this problem of underdetermination can be overcome with greater coordination across the biomarker research trajectory. I then sketch an account for how coordination across a research trajectory can be evaluated. I ultimate conclude that what makes a high-quality biomarker experiment must be judged by the epistemic contribution it makes to this coordinated research effort.
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| Item Type: | Published Article or Volume | ||||||
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| Additional Information: | ISSN: 0495-4548 (print) | ||||||
| Keywords: | biomarkers; personalised medicine; underdetermination; neurooncology | ||||||
| Subjects: | Specific Sciences > Biology General Issues > Experimentation Specific Sciences > Medicine |
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| Depositing User: | Unnamed user with email theoria@ehu.es | ||||||
| Date Deposited: | 07 Jun 2016 13:08 | ||||||
| Last Modified: | 07 Jun 2016 13:08 | ||||||
| Item ID: | 12147 | ||||||
| Journal or Publication Title: | THEORIA. An International Journal for Theory, History and Foundations of Science | ||||||
| Publisher: | Euskal Herriko Unibertsitatea / Universidad del País Vasco | ||||||
| Official URL: | http://www.ehu.eus/ojs/index.php/THEORIA/article/v... | ||||||
| DOI or Unique Handle: | 10.1387/theoria.12697 | ||||||
| Subjects: | Specific Sciences > Biology General Issues > Experimentation Specific Sciences > Medicine |
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| Date: | May 2015 | ||||||
| Page Range: | pp. 207-227 | ||||||
| Volume: | 30 | ||||||
| Number: | 2 | ||||||
| ISSN: | 2171-679X | ||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/12147 |
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