Laplane, Lucie (2018) Cancer stem cells modulate patterns and processes of evolution in cancers. [Preprint]
|
Text
BP-preprint-laplane.pdf Download (2MB) | Preview |
Abstract
The clonal evolution (CE) model and the cancer stem cell (CSC) model are two independent models of cancers, yet recent data shows intersections between the two models. This article explores the impacts of the CSC model on the CE model. I show that CSC restriction, which depends on CSC frequency in cancer cell populations and on the probability of dedifferentiation of cancer non-stem cells (non-CSC) into CSCs, can favor or impede some patterns of evolution (linear or branched evolution) and some processes of evolution (drift, evolution by natural selection, complex adaptations). Taking CSC restriction into account for the CE model thus has implications for the way in which we understand the patterns and processes of evolution, and can also provide new leads for therapeutic interventions.
Export/Citation: | EndNote | BibTeX | Dublin Core | ASCII/Text Citation (Chicago) | HTML Citation | OpenURL |
Social Networking: |
Item Type: | Preprint | ||||||
---|---|---|---|---|---|---|---|
Creators: |
|
||||||
Keywords: | Cancer stem cell; Clonal evolution; Cancer progression; Drift; Evolution by natural selection | ||||||
Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Medicine |
||||||
Depositing User: | Lucie Laplane | ||||||
Date Deposited: | 27 Apr 2018 15:41 | ||||||
Last Modified: | 27 Apr 2018 15:41 | ||||||
Item ID: | 14596 | ||||||
Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Medicine |
||||||
Date: | 25 April 2018 | ||||||
URI: | https://philsci-archive.pitt.edu/id/eprint/14596 |
Monthly Views for the past 3 years
Monthly Downloads for the past 3 years
Plum Analytics
Actions (login required)
View Item |