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The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End

Kumar, Manish (2023) The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End. [Preprint]

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Abstract

Cancer is a deadly genetic disease with diverse aspects of complexity, including cancer immune evasion, treatment resistance, and recurrence requiring optimized treatment to be cured. Molecular studies have revealed that tumors are profoundly heterogeneous in nature, leading to the complexity of cancer progression that is ultimately linked to its genetic machinery. It is important to note that patients with the same types of cancer respond differently to cancer treatments, indicating the need for patient-specific treatment options. This requires an in-depth genomic study of the patient's tumors to fully understand the driving factors of cancer for effective targeted therapy. Precision oncology has evolved as a form of cancer therapy focused on genetic profiling of tumors to identify molecular alterations involved in cancer development for tailored individualized treatment of the disease. Whole genome sequencing, tumor and cell-free DNA profiling, transcriptomics, proteomics and exploration of the cancer immune system form the basis of this field of cancer research and treatment. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of ongoing technological advancements in related fields of study in to assess its scope and importance in achieving effective cure against cancer.


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Item Type: Preprint
Creators:
CreatorsEmailORCID
Kumar, Manishkmanish125@yahoo.com0000-0002-6021-7063
Additional Information: Pictures and other related data have been taken from sources available for reuse freely or on request as per the requirements. Pictures no.1 and 2 have been added to the text with permission from Elsevier. (Order No. 5521991271884, dated 4th April 2023).
Keywords: Gene Mutation; Cancer Genomics; p53; K-Ras; C-Myc; Bcl-2, Cancer Stem Cells; Targeted Therapy; Immunotherapy, Precision Medicine
Subjects: Specific Sciences > Medicine > Health and Disease
Depositing User: Mr, Manish Kumar
Date Deposited: 15 Feb 2024 02:11
Last Modified: 15 Feb 2024 02:11
Item ID: 23092
Official URL: http://doi.org/10.14293/PR2199.000553.v1
DOI or Unique Handle: 10.14293/PR2199.000553.v1
Subjects: Specific Sciences > Medicine > Health and Disease
Date: 21 December 2023
URI: https://philsci-archive.pitt.edu/id/eprint/23092

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