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L’exposome : vers une science intégrative des expositions ?

Giroux, Élodie (2021) L’exposome : vers une science intégrative des expositions ? Lato Sensu, revue de la Société de philosophie des sciences, 8 (3). pp. 9-28. ISSN 2295-8029

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Abstract

The exposome refers to an emergent research field, the aim of which is to develop an integrated science of
the totality of exposures to which an individual is subjected over the course of their life and which influence
their health. There are two principal research orientations. One concentrates on the study of the internal
exposome, which makes it possible to identify the main exposures impacting on health by precisely measuring
them at the level of the biochemical environment of the body. The other aims to integrate social and
ecological exposures with biological and internal exposures and thus to develop a holistic model of environmental
health. Taking as its point of departure the examination of the scientific literature, the analysis
of the first generation of exposomic studies (2010-2020), and interviews conducted with epidemiologists
engaged in this research, this article offers a review of the promises and realizations of this emerging field
as regards the integration of exposures, while also seeking to offer a critical perspective on this topic. After
having presented the exposome and its diverse conceptions, I consider which type of integration is in play in
each of these two orientations, while also considering their interest and pertinence. The analysis concentrates
above all on the second orientation: what does this highly holistic approach have to offer as regards
the renewed integration of environmental and genetic factors, but also social and biological factors, in our
understanding of exposures and our explanation of disease?


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Item Type: Published Article or Volume
Creators:
CreatorsEmailORCID
Giroux, Élodieelodie.giroux@univ-lyon3.fr
Keywords: exposome, exposomique, épidémiologie moléculaire, épidémiologie sociale, incorporation, sociomarqueur, holisme, réductionnisme, exposition, environnement, intégration, biomarqueur, pluralisme, étiologie, causalité, déterminants sociaux
Subjects: Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Ecology/Conservation
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
Depositing User: Lato Sensu
Date Deposited: 09 Oct 2021 00:14
Last Modified: 09 Oct 2021 00:14
Item ID: 19659
Journal or Publication Title: Lato Sensu, revue de la Société de philosophie des sciences
Publisher: Société de philosophie des sciences
Official URL: https://ojs.uclouvain.be/index.php/latosensu/artic...
DOI or Unique Handle: dx.doi.org/10.20416/LSRSPS.V8I3.2
Subjects: Specific Sciences > Biology > Developmental Biology
Specific Sciences > Biology > Ecology/Conservation
Specific Sciences > Biology > Evolutionary Theory
Specific Sciences > Biology > Molecular Biology/Genetics
Date: 7 October 2021
Page Range: pp. 9-28
Volume: 8
Number: 3
ISSN: 2295-8029
URI: http://philsci-archive.pitt.edu/id/eprint/19659

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