Plutynski, Anya and Bertolaso, Marta (2018) What and How do Cancer Systems Biologists Explain? [Preprint]
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Abstract
In this article, we argue, first, that there are very different research projects that fall under the heading of “systems biology of cancer.” While they share some general features, they differ in their aims and theoretical commitments. Second, we argue that some explanations in systems biology of cancer are concerned with properties of signaling networks (such as robustness or fragility) and how they may play an important causal role in patterns of vulnerability to cancer. Further, some systems biological explanations are compelling illustrations of how “top-down” and “bottom-up” approaches to the same phenomena
may be integrated.
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| Item Type: | Preprint | |||||||||
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| Keywords: | systems biology, cancer, explanation, integration, networks | |||||||||
| Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Explanation |
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| Depositing User: | A Plutynski | |||||||||
| Date Deposited: | 16 Dec 2019 00:45 | |||||||||
| Last Modified: | 16 Dec 2019 00:45 | |||||||||
| Item ID: | 16726 | |||||||||
| Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Molecular Biology/Genetics General Issues > Explanation |
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| Date: | December 2018 | |||||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/16726 |
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