Kumar, Manish (2023) Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics. [Preprint]
This is the latest version of this item.
|
Text
ScienceOpen.000553.v2.pdf Download (948kB) | Preview |
Abstract
Cancer is a fatal genetic disease with different aspects of complexity, including cancer immune evasion, treatment resistance and recurrence, requiring optimized treatment for proper cure. Molecular studies have revealed that tumors are extremely heterogeneous in nature, leading to the complexity of cancer progression that is ultimately linked to its genetic machinery. It is important to note that patients with the same types of cancer respond differently to cancer treatments, indicating the need for treatment options specific to each patient. Thus, in-depth genomic study of patient’s tumor will be needed to fully understand the determinants of cancer initiation and progression for effective targeted therapy. Precision oncology has evolved as a form of cancer therapy focused on genetic profiling of tumors to identify molecular alterations involved in cancer manifestation for tailored individualized treatment of the disease. There has been a deluge of formulation and mass production of anticancer agents in recent years, mainly due to advances in genomic technologies enabling precise targeting of oncogenic pathways involved in disease. This article aims to briefly explain the foundations and frontiers of precision oncology in the context of advancements in the tools and techniques exploited in the process in order to assess its scope and importance to realize the intended goals.
| Export/Citation: | EndNote | BibTeX | Dublin Core | ASCII/Text Citation (Chicago) | HTML Citation | OpenURL |
| Social Networking: |
| Item Type: | Preprint | ||||||
|---|---|---|---|---|---|---|---|
| Creators: |
|
||||||
| Additional Information: | Pictures and other related data have been taken from sources freely available for reuse or permission for the same can be obtained upon request. Pictures no. 1 and 2 have been added to the text with permission from Elsevier. (Order No. 5521991271884, dated 4th April 2023). 49 pages, 2 figures, and 1 table. | ||||||
| Keywords: | Gene Mutation; Cancer Genomics; p53; K-Ras; C-Myc; Bcl-2, Cancer Stem Cells; Targeted Therapy; Immunotherapy, Precision Medicine | ||||||
| Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease |
||||||
| Depositing User: | Mr, Manish Kumar | ||||||
| Date Deposited: | 16 Jul 2024 06:02 | ||||||
| Last Modified: | 16 Jul 2024 06:02 | ||||||
| Item ID: | 23690 | ||||||
| Official URL: | https://www.scienceopen.com/document?vid=2776ab30-... | ||||||
| DOI or Unique Handle: | 10.14293/PR2199.000553.v2 | ||||||
| Subjects: | Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease |
||||||
| Date: | 21 December 2023 | ||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/23690 |
Available Versions of this Item
-
The Precision Oncology Approach to Molecular Cancer Therapeutics Targeting Oncogenic Signaling Pathways is a Means to an End. (deposited 15 Feb 2024 02:11)
- Precision Oncology, Signaling Pathways Reprogramming and Targeted Therapy: A Holistic Approach to Molecular Cancer Therapeutics. (deposited 16 Jul 2024 06:02) [Currently Displayed]
Monthly Views for the past 3 years
Monthly Downloads for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
 |
View Item |
![[feed]](http://philsci-archive.pitt.edu/style/images/feed-icon-32x32.png){kind=icon}