Greslehner, Gregor P. and Boem, Federico and Chiu, Lynn and Konsman, Jan Pieter (2023) Philosophical perspectives on neuroendocrine-immune interactions: the building block model and complementary ecological approaches. Neuroendocrine-Immune System Interactions. Masterclass in Neuroendocrinology, vol 13.

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Abstract

The study of the interactions between the neuroendocrine and immune systems is a highly interdisciplinary research endeavor, in which the boundaries between the systems being studied become blurred. We address a common scientific perspective in dealing with intertwined complex systems, namely the conceptual approach in science that treats each system (e.g., nervous, immune, endocrine systems) as separate units or “building blocks” with unique functions that correspond to specific structures. While there are merits to this way of decomposing complex systems, there are several reasons why such an approach is limited when trying to recompose a physiological system that is engaged in intricate co-functioning and that is the result of, co-development, and co-evolution, not just between these systems, but with the gut microbiota as well. Our suggestion is to take an alternative ecological evolutionary developmental approach to the neuro-endocrine-immune-microbiota system (NEIMS) as a whole, which can serve as complementary to the predominant building block perspective.

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Item Type:	Published Article or Volume
Creators:	Creators Email ORCID Greslehner, Gregor P. gregor.greslehner@univie.ac.at 0000-0002-4072-8229 Boem, Federico Chiu, Lynn Konsman, Jan Pieter
Keywords:	neuroimmunology; immunology; modeling; philosophy of science
Subjects:	Specific Sciences > Biology Specific Sciences > Neuroscience > Cognitive Neuroscience General Issues > Models and Idealization
Depositing User:	Dr. Gregor P. Greslehner
Date Deposited:	16 Jan 2025 14:32
Last Modified:	16 Jan 2025 14:32
Item ID:	24559
Journal or Publication Title:	Neuroendocrine-Immune System Interactions. Masterclass in Neuroendocrinology, vol 13
Publisher:	Springer
Official URL:	https://link.springer.com/chapter/10.1007/978-3-03...
DOI or Unique Handle:	https://doi.org/10.1007/978-3-031-21358-8_2
Subjects:	Specific Sciences > Biology Specific Sciences > Neuroscience > Cognitive Neuroscience General Issues > Models and Idealization
Date:	4 March 2023
URI:	https://philsci-archive.pitt.edu/id/eprint/24559

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