Pradeu, Thomas and Daignan‐Fornier, Bertrand and Ewald, Andrew and Germain, Pierre‐Luc and Okasha, Samir and Plutynski, Anya and Benzekry, Sébastien and Bertolaso, Marta and Bissell, Mina and Brown, Joel S. and Chin‐Yee, Benjamin and Chin‐Yee, Ian and Clevers, Hans and Cognet, Laurent and Darrason, Marie and Farge, Emmanuel and Feunteun, Jean and Galon, Jérôme and Giroux, Elodie and Green, Sara and Gross, Fridolin and Jaulin, Fanny and Knight, Rob and Laconi, Ezio and Larmonier, Nicolas and Maley, Carlo and Mantovani, Alberto and Moreau, Violaine and Nassoy, Pierre and Rondeau, Elena and Santamaria, David and Sawai, Catherine M. and Seluanov, Andrei and Sepich‐Poore, Gregory D. and Sisirak, Vanja and Solary, Eric and Yvonnet, Sarah and Laplane, Lucie (2023) Reuniting philosophy and science to advance cancer research. Biological Reviews. ISSN 1464-7931
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Abstract
Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.
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| Item Type: | Published Article or Volume | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Keywords: | Driver Mutation, Clonal Evolution, Multicellularity, Tumorigenesis, Microenvironment, Oncoimmunology, Cancer Stem Cells, Philosophy of Cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Developmental Biology Specific Sciences > Biology > Ecology/Conservation Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease Specific Sciences > Medicine |
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| Depositing User: | Thomas Pradeu | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date Deposited: | 10 Jul 2023 13:50 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified: | 10 Jul 2023 13:50 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Item ID: | 22296 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Biological Reviews | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Official URL: | http://doi.org/10.1111/brv.12971 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI or Unique Handle: | 10.1111/brv.12971 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | Specific Sciences > Biology Specific Sciences > Biology > Developmental Biology Specific Sciences > Biology > Ecology/Conservation Specific Sciences > Biology > Evolutionary Theory Specific Sciences > Biology > Molecular Biology/Genetics Specific Sciences > Medicine > Health and Disease Specific Sciences > Medicine |
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| Date: | 2023 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1464-7931 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| URI: | https://philsci-archive.pitt.edu/id/eprint/22296 |
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